Target name

P14780: Matrix metalloproteinase-9


  Protein function

May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.

  Database links

Uniprot primary ID P14780
PDB ID 2OW0 1LKG 1GKC 2OVX 1GKD 2OW1 2OVZ 4H2E 2OW2 1L6J 4H3X 4H1Q 4WZV 4HMA 4H82 4JIJ 1ITV 4XCT 4JQG
DrugBank ID DB01017 DB00786 DB01296 DB01197
BioGrid ID 110461
GuidetoPHARMACOLOGY ID 1633
PharmGKB ID PA30889
KEGG ID hsa:4318
DIP ID DIP-29518N
STRING ID 9606.ENSP00000361405
IntAct ID P14780
DMDM 269849668
BRENDA 3.4.24.35
Reactome R-HSA-1433557 R-HSA-3928665 R-HSA-1474228 R-HSA-1442490 R-HSA-1592389 R-HSA-2022090
SignaLink
BioCyc
Entrez Gene (Gene ID) 4318
BindingDB P14780

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.896 0.005 0.930 0.000 0.913 0.005 0.911 0.003 0.970 0.000 0.828 0.004 Download
Estate fingerprints 0.890 0.000 0.850 0.004 0.870 0.000 0.873 0.005 0.940 0.000 0.743 0.007 Download
MACCS fingerprints 0.780 0.000 0.892 0.003 0.836 0.005 0.829 0.003 0.940 0.000 0.674 0.005 Download
Daylight fingerprints 0.787 0.005 0.839 0.006 0.813 0.005 0.810 0.000 0.896 0.005 0.632 0.006 Download
ECFP2 fingerprints 0.960 0.000 0.960 0.005 0.960 0.000 0.960 0.000 0.990 0.000 0.921 0.006 Download
ECFP4 fingerprints 0.966 0.005 0.974 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.939 0.003 Download
ECFP6 fingerprints 0.956 0.005 0.980 0.000 0.968 0.004 0.968 0.004 0.990 0.000 0.936 0.005 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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