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E-mail: biomed@csu.edu.cn
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May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
| Uniprot primary ID | P14780 |
| PDB ID | 2OW0 1LKG 1GKC 2OVX 1GKD 2OW1 2OVZ 4H2E 2OW2 1L6J 4H3X 4H1Q 4WZV 4HMA 4H82 4JIJ 1ITV 4XCT 4JQG |
| DrugBank ID | DB01017 DB00786 DB01296 DB01197 |
| BioGrid ID | 110461 |
| GuidetoPHARMACOLOGY ID | 1633 |
| PharmGKB ID | PA30889 |
| KEGG ID | hsa:4318 |
| DIP ID | DIP-29518N |
| STRING ID | 9606.ENSP00000361405 |
| IntAct ID | P14780 |
| DMDM | 269849668 |
| BRENDA | 3.4.24.35 |
| Reactome | R-HSA-1433557 R-HSA-3928665 R-HSA-1474228 R-HSA-1442490 R-HSA-1592389 R-HSA-2022090 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 4318 |
| BindingDB | P14780 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.896 | 0.005 | 0.930 | 0.000 | 0.913 | 0.005 | 0.911 | 0.003 | 0.970 | 0.000 | 0.828 | 0.004 | Download |
| Estate fingerprints | 0.890 | 0.000 | 0.850 | 0.004 | 0.870 | 0.000 | 0.873 | 0.005 | 0.940 | 0.000 | 0.743 | 0.007 | Download |
| MACCS fingerprints | 0.780 | 0.000 | 0.892 | 0.003 | 0.836 | 0.005 | 0.829 | 0.003 | 0.940 | 0.000 | 0.674 | 0.005 | Download |
| Daylight fingerprints | 0.787 | 0.005 | 0.839 | 0.006 | 0.813 | 0.005 | 0.810 | 0.000 | 0.896 | 0.005 | 0.632 | 0.006 | Download |
| ECFP2 fingerprints | 0.960 | 0.000 | 0.960 | 0.005 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.921 | 0.006 | Download |
| ECFP4 fingerprints | 0.966 | 0.005 | 0.974 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.939 | 0.003 | Download |
| ECFP6 fingerprints | 0.956 | 0.005 | 0.980 | 0.000 | 0.968 | 0.004 | 0.968 | 0.004 | 0.990 | 0.000 | 0.936 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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