Target name

P15121: Aldose reductase


  Protein function

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

  Database links

Uniprot primary ID P15121
PDB ID 4PUW 1ADS 4PUU 3S3G 1T41 2F2K 3MC5 4QX4 3T42 2IQ0 1PWL 1PWM 1ABN 4LB3 4PRT 4LB4 2INZ 1MAR 1Z8A 4QR6 3M64 4NKC 1XGD 4GQ0 1US0 2INE 2IPW 1EF3 2FZD 4IGS 4LBR 4LBS 2FZ8 2FZ9 3MB9 3G5E 3BCJ 2PZN 1Z89 2AGT 2PEV 3ONB 3ONC 4PR4 3Q67 1Z3N 4PRR 2DUX 2DUZ 3DN5 3LD5
DrugBank ID DB00605
BioGrid ID 106732
GuidetoPHARMACOLOGY ID 2768
PharmGKB ID PA24675
KEGG ID hsa:231
DIP ID
STRING ID 9606.ENSP00000285930
IntAct ID P15121
DMDM 113596
BRENDA 1.1.1.21 1.1.1.188
Reactome R-HSA-5652227 R-HSA-196108
SignaLink
BioCyc MetaCyc:HS01502-MONOMER
Entrez Gene (Gene ID) 231
BindingDB P15121

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.695 0.010 0.993 0.000 0.844 0.005 0.816 0.005 0.970 0.000 0.717 0.007 Download
Estate fingerprints 0.765 0.005 0.861 0.005 0.813 0.005 0.804 0.005 0.900 0.000 0.627 0.009 Download
MACCS fingerprints 0.916 0.005 0.882 0.005 0.899 0.003 0.900 0.000 0.969 0.003 0.795 0.005 Download
Daylight fingerprints 0.707 0.005 0.929 0.005 0.818 0.004 0.791 0.003 0.840 0.000 0.647 0.005 Download
ECFP2 fingerprints 0.978 0.004 0.944 0.005 0.961 0.003 0.962 0.004 0.990 0.000 0.925 0.005 Download
ECFP4 fingerprints 0.966 0.005 0.986 0.000 0.976 0.005 0.976 0.005 1.000 0.000 0.949 0.006 Download
ECFP6 fingerprints 0.928 0.004 0.992 0.003 0.960 0.000 0.958 0.004 0.991 0.003 0.918 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn