Target name

P15207: Androgen receptor


  Protein function

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity).

  Database links

Uniprot primary ID P15207
PDB ID 1I37 1XNN 1R4I 2IHQ 1I38 2NW4 3G0W
DrugBank ID
BioGrid ID 246396
GuidetoPHARMACOLOGY ID 628
PharmGKB ID
KEGG ID rno:24208
DIP ID DIP-5963N
STRING ID 10116.ENSRNOP00000009129
IntAct ID P15207
DMDM
BRENDA
Reactome R-RNO-5625886 R-RNO-383280
SignaLink
BioCyc
Entrez Gene (Gene ID) 24208
BindingDB P15207

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.920 0.000 0.862 0.006 0.891 0.003 0.893 0.005 0.960 0.000 0.788 0.008 Download
Estate fingerprints 0.883 0.007 0.905 0.005 0.894 0.005 0.894 0.005 0.960 0.000 0.789 0.006 Download
MACCS fingerprints 0.927 0.008 0.873 0.008 0.900 0.008 0.902 0.006 0.950 0.000 0.802 0.013 Download
Daylight fingerprints 0.766 0.011 0.788 0.000 0.777 0.005 0.774 0.008 0.851 0.003 0.556 0.011 Download
ECFP2 fingerprints 0.949 0.003 0.967 0.004 0.958 0.004 0.956 0.005 0.990 0.000 0.915 0.005 Download
ECFP4 fingerprints 0.950 0.000 0.966 0.004 0.958 0.004 0.952 0.004 0.990 0.000 0.912 0.004 Download
ECFP6 fingerprints 0.958 0.006 0.966 0.004 0.962 0.004 0.962 0.004 0.992 0.004 0.928 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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