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E-mail: biomed@csu.edu.cn
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Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity).
| Uniprot primary ID | P15207 |
| PDB ID | 1I37 1XNN 1R4I 2IHQ 1I38 2NW4 3G0W |
| DrugBank ID | |
| BioGrid ID | 246396 |
| GuidetoPHARMACOLOGY ID | 628 |
| PharmGKB ID | |
| KEGG ID | rno:24208 |
| DIP ID | DIP-5963N |
| STRING ID | 10116.ENSRNOP00000009129 |
| IntAct ID | P15207 |
| DMDM | |
| BRENDA | |
| Reactome | R-RNO-5625886 R-RNO-383280 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 24208 |
| BindingDB | P15207 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.920 | 0.000 | 0.862 | 0.006 | 0.891 | 0.003 | 0.893 | 0.005 | 0.960 | 0.000 | 0.788 | 0.008 | Download |
| Estate fingerprints | 0.883 | 0.007 | 0.905 | 0.005 | 0.894 | 0.005 | 0.894 | 0.005 | 0.960 | 0.000 | 0.789 | 0.006 | Download |
| MACCS fingerprints | 0.927 | 0.008 | 0.873 | 0.008 | 0.900 | 0.008 | 0.902 | 0.006 | 0.950 | 0.000 | 0.802 | 0.013 | Download |
| Daylight fingerprints | 0.766 | 0.011 | 0.788 | 0.000 | 0.777 | 0.005 | 0.774 | 0.008 | 0.851 | 0.003 | 0.556 | 0.011 | Download |
| ECFP2 fingerprints | 0.949 | 0.003 | 0.967 | 0.004 | 0.958 | 0.004 | 0.956 | 0.005 | 0.990 | 0.000 | 0.915 | 0.005 | Download |
| ECFP4 fingerprints | 0.950 | 0.000 | 0.966 | 0.004 | 0.958 | 0.004 | 0.952 | 0.004 | 0.990 | 0.000 | 0.912 | 0.004 | Download |
| ECFP6 fingerprints | 0.958 | 0.006 | 0.966 | 0.004 | 0.962 | 0.004 | 0.962 | 0.004 | 0.992 | 0.004 | 0.928 | 0.006 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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