Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
| Uniprot primary ID | P15538 |
| PDB ID | |
| DrugBank ID | DB00501 DB01110 DB01026 DB00741 DB00252 DB01011 DB01233 |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 1359 |
| PharmGKB ID | PA133 |
| KEGG ID | hsa:1584 |
| DIP ID | |
| STRING ID | 9606.ENSP00000292427 |
| IntAct ID | |
| DMDM | 215274267 |
| BRENDA | 1.14.15.4 |
| Reactome | R-HSA-194002 R-HSA-211976 R-HSA-5579017 |
| SignaLink | |
| BioCyc | MetaCyc:HS08547-MONOMER |
| Entrez Gene (Gene ID) | 1584 |
| BindingDB | P15538 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.962 | 0.004 | 0.940 | 0.000 | 0.951 | 0.003 | 0.951 | 0.003 | 0.990 | 0.000 | 0.902 | 0.004 | Download |
| Estate fingerprints | 0.863 | 0.007 | 0.877 | 0.005 | 0.870 | 0.005 | 0.869 | 0.003 | 0.950 | 0.000 | 0.739 | 0.006 | Download |
| MACCS fingerprints | 0.917 | 0.005 | 0.883 | 0.005 | 0.900 | 0.000 | 0.900 | 0.000 | 0.950 | 0.000 | 0.800 | 0.007 | Download |
| Daylight fingerprints | 0.845 | 0.005 | 0.835 | 0.000 | 0.840 | 0.000 | 0.840 | 0.000 | 0.870 | 0.000 | 0.680 | 0.008 | Download |
| ECFP2 fingerprints | 0.989 | 0.003 | 0.971 | 0.003 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.961 | 0.003 | Download |
| ECFP4 fingerprints | 0.991 | 0.003 | 0.991 | 0.000 | 0.991 | 0.003 | 0.991 | 0.003 | 1.000 | 0.000 | 0.982 | 0.004 | Download |
| ECFP6 fingerprints | 0.990 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.980 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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