Target name

P15538: Cytochrome P450 11B1, mitochondrial


  Protein function

Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.

  Database links

Uniprot primary ID P15538
PDB ID
DrugBank ID DB00501 DB01110 DB01026 DB00741 DB00252 DB01011 DB01233
BioGrid ID
GuidetoPHARMACOLOGY ID 1359
PharmGKB ID PA133
KEGG ID hsa:1584
DIP ID
STRING ID 9606.ENSP00000292427
IntAct ID
DMDM 215274267
BRENDA 1.14.15.4
Reactome R-HSA-194002 R-HSA-211976 R-HSA-5579017
SignaLink
BioCyc MetaCyc:HS08547-MONOMER
Entrez Gene (Gene ID) 1584
BindingDB P15538

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.962 0.004 0.940 0.000 0.951 0.003 0.951 0.003 0.990 0.000 0.902 0.004 Download
Estate fingerprints 0.863 0.007 0.877 0.005 0.870 0.005 0.869 0.003 0.950 0.000 0.739 0.006 Download
MACCS fingerprints 0.917 0.005 0.883 0.005 0.900 0.000 0.900 0.000 0.950 0.000 0.800 0.007 Download
Daylight fingerprints 0.845 0.005 0.835 0.000 0.840 0.000 0.840 0.000 0.870 0.000 0.680 0.008 Download
ECFP2 fingerprints 0.989 0.003 0.971 0.003 0.980 0.000 0.980 0.000 1.000 0.000 0.961 0.003 Download
ECFP4 fingerprints 0.991 0.003 0.991 0.000 0.991 0.003 0.991 0.003 1.000 0.000 0.982 0.004 Download
ECFP6 fingerprints 0.990 0.000 0.990 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.980 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn