Target name

P15917: Lethal factor


  Protein function

One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. LF is the lethal factor that, when associated with PA, causes death. LF is not toxic by itself. It is a protease that cleaves the N-terminal of most dual specificity mitogen-activated protein kinase kinases (MAPKKs or MAP2Ks) (except for MAP2K5). Cleavage invariably occurs within the N-terminal proline-rich region preceding the kinase domain, thus disrupting a sequence involved in directing specific protein-protein interactions necessary for the assembly of signaling complexes. There may be other cytosolic targets of LF involved in cytotoxicity. The proteasome may mediate a toxic process initiated by LF in the cell cytosol involving degradation of unidentified molecules that are essential for macrophage homeostasis. This is an early step in LeTx intoxication, but it is downstream of the cleavage by LF of MEK1 or other putative substrates.

  Database links

Uniprot primary ID P15917
PDB ID 1ZXV 4DV8 4WF6 1PWV 1PWW 1PWU 2L0R 1PWP 1PWQ 1YQY 3KWV 1JKY 1J7N 4PKQ 4PKS 4PKR 4PKU 4PKT 4PKW 4PKV
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID bar:GBAA_pXO1_0172 pg:3361711
DIP ID DIP-29871N
STRING ID
IntAct ID P15917
DMDM
BRENDA 3.4.24.83
Reactome R-HSA-5210891
SignaLink
BioCyc ANTHRA:GBAA_PXO1_0172-MONOMER;BANT261594:GJ7F-5757-MONOMER
Entrez Gene (Gene ID) 3361711
BindingDB P15917

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.813 0.007 0.947 0.004 0.880 0.005 0.871 0.003 0.931 0.003 0.767 0.011 Download
Estate fingerprints 0.836 0.007 0.814 0.010 0.825 0.005 0.829 0.006 0.890 0.000 0.651 0.010 Download
MACCS fingerprints 0.869 0.007 0.821 0.005 0.845 0.005 0.848 0.004 0.900 0.000 0.691 0.007 Download
Daylight fingerprints 0.774 0.010 0.802 0.005 0.788 0.006 0.786 0.007 0.840 0.000 0.577 0.012 Download
ECFP2 fingerprints 0.891 0.006 0.921 0.008 0.906 0.007 0.906 0.007 0.970 0.000 0.811 0.009 Download
ECFP4 fingerprints 0.895 0.008 0.947 0.005 0.921 0.003 0.918 0.004 0.980 0.000 0.844 0.005 Download
ECFP6 fingerprints 0.879 0.003 0.969 0.004 0.924 0.005 0.920 0.000 0.977 0.005 0.851 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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