Target name

P16050: Arachidonate 15-lipoxygenase


  Protein function

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.

  Database links

Uniprot primary ID P16050
PDB ID 2ABT
DrugBank ID
BioGrid ID 106747
GuidetoPHARMACOLOGY ID
PharmGKB ID PA48
KEGG ID hsa:246
DIP ID DIP-60388N
STRING ID 9606.ENSP00000293761
IntAct ID
DMDM 126396
BRENDA 1.13.11.33
Reactome R-HSA-2142712 R-HSA-2142691 R-HSA-2142770
SignaLink
BioCyc MetaCyc:HS08621-MONOMER
Entrez Gene (Gene ID) 246
BindingDB P16050

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.917 0.007 0.923 0.003 0.920 0.000 0.920 0.000 0.957 0.005 0.846 0.005 Download
Estate fingerprints 0.905 0.005 0.813 0.010 0.859 0.007 0.864 0.005 0.904 0.005 0.722 0.013 Download
MACCS fingerprints 0.898 0.004 0.854 0.006 0.876 0.007 0.877 0.005 0.919 0.003 0.744 0.011 Download
Daylight fingerprints 0.851 0.006 0.793 0.000 0.822 0.004 0.829 0.003 0.860 0.000 0.651 0.006 Download
ECFP2 fingerprints 0.969 0.003 0.895 0.006 0.932 0.006 0.937 0.005 0.970 0.000 0.870 0.012 Download
ECFP4 fingerprints 0.950 0.000 0.908 0.003 0.929 0.003 0.930 0.000 0.970 0.000 0.868 0.006 Download
ECFP6 fingerprints 0.940 0.000 0.938 0.008 0.939 0.006 0.939 0.006 0.970 0.000 0.879 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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