Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
| Uniprot primary ID | P16184 |
| PDB ID | 1DAJ 1S3Y 2CD2 3TD8 3NZA 3NZC 3NZB 4G8Z 3CD2 2FZH 2FZI 4IXE 4IXG 4IXF 4CD2 1DYR 1KLK 4QJZ 3NZ9 1E26 1CD2 3NZ6 1VJ3 1LY3 1LY4 |
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| BRENDA | 1.5.1.3 |
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| BindingDB | P16184 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
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| FP2 fingerprints | 0.969 | 0.003 | 0.987 | 0.000 | 0.978 | 0.004 | 0.978 | 0.004 | 0.990 | 0.000 | 0.949 | 0.003 | Download |
| Estate fingerprints | 0.932 | 0.004 | 0.950 | 0.000 | 0.941 | 0.003 | 0.941 | 0.003 | 0.990 | 0.000 | 0.884 | 0.005 | Download |
| MACCS fingerprints | 0.969 | 0.003 | 0.971 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 1.000 | 0.000 | 0.944 | 0.005 | Download |
| Daylight fingerprints | 0.897 | 0.005 | 0.983 | 0.005 | 0.940 | 0.000 | 0.939 | 0.003 | 0.990 | 0.000 | 0.886 | 0.005 | Download |
| ECFP2 fingerprints | 1.000 | 0.000 | 0.980 | 0.003 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.980 | 0.000 | Download |
| ECFP4 fingerprints | 0.999 | 0.003 | 0.993 | 0.000 | 0.996 | 0.005 | 0.996 | 0.005 | 1.000 | 0.000 | 0.989 | 0.003 | Download |
| ECFP6 fingerprints | 0.990 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.990 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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