Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis (By similarity). Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:2555358).
| Uniprot primary ID | P16257 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 2879 |
| PharmGKB ID | |
| KEGG ID | rno:24230 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000014089 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | |
| SignaLink | |
| BioCyc | RETL1328306-WGS:GSTH-6241-MONOMER |
| Entrez Gene (Gene ID) | 24230 |
| BindingDB | P16257 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.870 | 0.005 | 0.936 | 0.000 | 0.903 | 0.005 | 0.900 | 0.005 | 0.970 | 0.000 | 0.811 | 0.006 | Download |
| Estate fingerprints | 0.889 | 0.003 | 0.871 | 0.005 | 0.880 | 0.000 | 0.880 | 0.000 | 0.950 | 0.000 | 0.759 | 0.003 | Download |
| MACCS fingerprints | 0.927 | 0.005 | 0.851 | 0.005 | 0.889 | 0.003 | 0.890 | 0.000 | 0.960 | 0.000 | 0.777 | 0.005 | Download |
| Daylight fingerprints | 0.810 | 0.000 | 0.830 | 0.000 | 0.820 | 0.000 | 0.820 | 0.000 | 0.860 | 0.000 | 0.640 | 0.000 | Download |
| ECFP2 fingerprints | 0.970 | 0.000 | 0.968 | 0.000 | 0.969 | 0.003 | 0.969 | 0.003 | 1.000 | 0.000 | 0.936 | 0.005 | Download |
| ECFP4 fingerprints | 0.990 | 0.000 | 0.990 | 0.005 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.979 | 0.003 | Download |
| ECFP6 fingerprints | 0.964 | 0.005 | 0.996 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.958 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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