Target name

P16581: E-selectin


  Protein function

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

  Database links

Uniprot primary ID P16581
PDB ID 1KJA 1ESL 1G1T 4C16 4CSY
DrugBank ID DB01136
BioGrid ID 112301
GuidetoPHARMACOLOGY ID
PharmGKB ID PA35640
KEGG ID hsa:6401
DIP ID DIP-58639N
STRING ID 9606.ENSP00000331736
IntAct ID P16581
DMDM 126180
BRENDA
Reactome R-HSA-202733
SignaLink
BioCyc
Entrez Gene (Gene ID) 6401
BindingDB P16581

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.889 0.003 1.000 0.000 0.949 0.003 0.940 0.000 0.989 0.003 0.899 0.003 Download
Estate fingerprints 0.910 0.000 0.950 0.004 0.930 0.000 0.930 0.000 0.970 0.000 0.862 0.004 Download
MACCS fingerprints 0.886 0.010 0.934 0.009 0.910 0.000 0.909 0.003 0.980 0.000 0.825 0.005 Download
Daylight fingerprints 0.868 0.004 0.992 0.000 0.930 0.000 0.928 0.004 0.978 0.004 0.878 0.004 Download
ECFP2 fingerprints 0.910 0.007 0.990 0.003 0.950 0.000 0.947 0.005 0.990 0.000 0.899 0.007 Download
ECFP4 fingerprints 0.900 0.009 1.000 0.003 0.952 0.006 0.947 0.005 0.990 0.000 0.904 0.008 Download
ECFP6 fingerprints 0.880 0.000 1.000 0.000 0.940 0.000 0.934 0.005 0.992 0.004 0.884 0.005 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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