Capsid scaffolding protein: Acts as a scaffold protein by binding major capsid protein VP5 in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as VP5 forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein VP5. Cleavages products are evicted from the capsid before or during DNA packaging.
| Uniprot primary ID | P16753 |
| PDB ID | 1IED 1IEG 1IEF 1CMV 1IEC 1NJT 1LAY 1ID4 1JQ7 2WPO 1NJU 1NKK 1JQ6 1NKM 1WPO |
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| BindingDB | P16753 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.893 | 0.007 | 0.967 | 0.005 | 0.930 | 0.005 | 0.925 | 0.005 | 0.981 | 0.003 | 0.857 | 0.008 | Download |
| Estate fingerprints | 0.817 | 0.012 | 0.785 | 0.012 | 0.801 | 0.011 | 0.804 | 0.013 | 0.888 | 0.004 | 0.601 | 0.026 | Download |
| MACCS fingerprints | 0.897 | 0.008 | 0.879 | 0.011 | 0.888 | 0.008 | 0.888 | 0.008 | 0.948 | 0.004 | 0.771 | 0.015 | Download |
| Daylight fingerprints | 0.784 | 0.015 | 0.984 | 0.008 | 0.884 | 0.008 | 0.869 | 0.010 | 0.971 | 0.003 | 0.781 | 0.014 | Download |
| ECFP2 fingerprints | 0.976 | 0.007 | 0.952 | 0.007 | 0.964 | 0.005 | 0.964 | 0.005 | 1.000 | 0.000 | 0.926 | 0.008 | Download |
| ECFP4 fingerprints | 0.990 | 0.000 | 0.984 | 0.005 | 0.987 | 0.005 | 0.987 | 0.005 | 1.000 | 0.000 | 0.974 | 0.005 | Download |
| ECFP6 fingerprints | 0.973 | 0.005 | 0.993 | 0.000 | 0.983 | 0.005 | 0.983 | 0.005 | 1.000 | 0.000 | 0.968 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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