Target name

P16753: Capsid scaffolding protein


  Protein function

Capsid scaffolding protein: Acts as a scaffold protein by binding major capsid protein VP5 in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as VP5 forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein VP5. Cleavages products are evicted from the capsid before or during DNA packaging.

  Database links

Uniprot primary ID P16753
PDB ID 1IED 1IEG 1IEF 1CMV 1IEC 1NJT 1LAY 1ID4 1JQ7 2WPO 1NJU 1NKK 1JQ6 1NKM 1WPO
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID
DIP ID
STRING ID
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID)
BindingDB P16753

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.893 0.007 0.967 0.005 0.930 0.005 0.925 0.005 0.981 0.003 0.857 0.008 Download
Estate fingerprints 0.817 0.012 0.785 0.012 0.801 0.011 0.804 0.013 0.888 0.004 0.601 0.026 Download
MACCS fingerprints 0.897 0.008 0.879 0.011 0.888 0.008 0.888 0.008 0.948 0.004 0.771 0.015 Download
Daylight fingerprints 0.784 0.015 0.984 0.008 0.884 0.008 0.869 0.010 0.971 0.003 0.781 0.014 Download
ECFP2 fingerprints 0.976 0.007 0.952 0.007 0.964 0.005 0.964 0.005 1.000 0.000 0.926 0.008 Download
ECFP4 fingerprints 0.990 0.000 0.984 0.005 0.987 0.005 0.987 0.005 1.000 0.000 0.974 0.005 Download
ECFP6 fingerprints 0.973 0.005 0.993 0.000 0.983 0.005 0.983 0.005 1.000 0.000 0.968 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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