Target name

P18084: Integrin beta-5


  Protein function

Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.

  Database links

Uniprot primary ID P18084
PDB ID
DrugBank ID
BioGrid ID 109899
GuidetoPHARMACOLOGY ID
PharmGKB ID PA29959
KEGG ID hsa:3693
DIP ID
STRING ID 9606.ENSP00000296181
IntAct ID P18084
DMDM 124970
BRENDA
Reactome R-HSA-216083 R-HSA-2129379 R-HSA-1236973 R-HSA-3000178 R-HSA-3000170 R-HSA-445355
SignaLink P18084
BioCyc
Entrez Gene (Gene ID) 3693
BindingDB P18084

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.907 0.008 0.947 0.005 0.927 0.007 0.923 0.005 0.980 0.000 0.853 0.008 Download
Estate fingerprints 0.962 0.004 0.846 0.007 0.904 0.005 0.909 0.006 0.969 0.003 0.813 0.009 Download
MACCS fingerprints 0.957 0.009 0.907 0.005 0.932 0.004 0.936 0.005 0.971 0.003 0.865 0.012 Download
Daylight fingerprints 0.824 0.008 0.924 0.000 0.874 0.005 0.868 0.004 0.905 0.005 0.752 0.008 Download
ECFP2 fingerprints 0.971 0.006 0.965 0.006 0.968 0.004 0.968 0.004 0.990 0.000 0.933 0.007 Download
ECFP4 fingerprints 0.977 0.009 0.987 0.000 0.982 0.004 0.982 0.004 0.998 0.004 0.968 0.008 Download
ECFP6 fingerprints 0.937 0.007 0.995 0.000 0.966 0.005 0.966 0.005 0.999 0.003 0.935 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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