Target name

P18089: Alpha-2B adrenergic receptor


  Protein function

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.

  Database links

Uniprot primary ID P18089
PDB ID 2CVA
DrugBank ID DB06148 DB00925 DB01142 DB01049 DB05271 DB00734 DB00246
BioGrid ID 106660
GuidetoPHARMACOLOGY ID 26
PharmGKB ID PA36
KEGG ID hsa:151
DIP ID DIP-61453N
STRING ID 9606.ENSP00000387281
IntAct ID P18089
DMDM 27151763
BRENDA
Reactome R-HSA-418594 R-HSA-418597 R-HSA-390696 R-HSA-392023
SignaLink P18089
BioCyc
Entrez Gene (Gene ID) 151
BindingDB P18089

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.756 0.005 0.870 0.011 0.813 0.005 0.802 0.004 0.894 0.005 0.631 0.010 Download
Estate fingerprints 0.765 0.005 0.813 0.007 0.789 0.003 0.785 0.005 0.870 0.000 0.578 0.010 Download
MACCS fingerprints 0.874 0.007 0.704 0.007 0.789 0.006 0.808 0.004 0.885 0.005 0.589 0.011 Download
Daylight fingerprints 0.628 0.006 0.758 0.003 0.693 0.005 0.671 0.003 0.753 0.005 0.387 0.007 Download
ECFP2 fingerprints 0.898 0.004 0.862 0.004 0.880 0.000 0.883 0.005 0.943 0.005 0.759 0.009 Download
ECFP4 fingerprints 0.898 0.004 0.902 0.006 0.900 0.000 0.900 0.000 0.960 0.000 0.802 0.006 Download
ECFP6 fingerprints 0.850 0.008 0.916 0.003 0.883 0.005 0.880 0.005 0.960 0.000 0.772 0.008 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn