This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).
| Uniprot primary ID | P18130 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | |
| KEGG ID | bta:282134 |
| DIP ID | |
| STRING ID | 9913.ENSBTAP00000042306 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 282134 |
| BindingDB | P18130 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.865 | 0.011 | 0.923 | 0.008 | 0.894 | 0.007 | 0.888 | 0.006 | 0.949 | 0.003 | 0.785 | 0.010 | Download |
| Estate fingerprints | 0.773 | 0.012 | 0.797 | 0.007 | 0.785 | 0.008 | 0.784 | 0.010 | 0.860 | 0.000 | 0.571 | 0.016 | Download |
| MACCS fingerprints | 0.831 | 0.006 | 0.795 | 0.007 | 0.813 | 0.007 | 0.817 | 0.005 | 0.903 | 0.005 | 0.629 | 0.010 | Download |
| Daylight fingerprints | 0.801 | 0.016 | 0.851 | 0.014 | 0.826 | 0.012 | 0.822 | 0.012 | 0.909 | 0.009 | 0.652 | 0.021 | Download |
| ECFP2 fingerprints | 0.904 | 0.007 | 0.814 | 0.010 | 0.859 | 0.006 | 0.867 | 0.008 | 0.959 | 0.003 | 0.723 | 0.013 | Download |
| ECFP4 fingerprints | 0.922 | 0.006 | 0.902 | 0.005 | 0.912 | 0.004 | 0.912 | 0.004 | 0.974 | 0.005 | 0.826 | 0.005 | Download |
| ECFP6 fingerprints | 0.899 | 0.006 | 0.957 | 0.003 | 0.928 | 0.004 | 0.926 | 0.005 | 0.970 | 0.000 | 0.856 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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