TargetNet
  Target name

P18130: Alpha-1A adrenergic receptor

  Protein function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).

  Database links
Uniprot primary ID P18130
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID bta:282134
DIP ID
STRING ID 9913.ENSBTAP00000042306
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 282134
BindingDB P18130
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.865 0.011 0.923 0.008 0.894 0.007 0.888 0.006 0.949 0.003 0.785 0.010 Download
Estate fingerprints 0.773 0.012 0.797 0.007 0.785 0.008 0.784 0.010 0.860 0.000 0.571 0.016 Download
MACCS fingerprints 0.831 0.006 0.795 0.007 0.813 0.007 0.817 0.005 0.903 0.005 0.629 0.010 Download
Daylight fingerprints 0.801 0.016 0.851 0.014 0.826 0.012 0.822 0.012 0.909 0.009 0.652 0.021 Download
ECFP2 fingerprints 0.904 0.007 0.814 0.010 0.859 0.006 0.867 0.008 0.959 0.003 0.723 0.013 Download
ECFP4 fingerprints 0.922 0.006 0.902 0.005 0.912 0.004 0.912 0.004 0.974 0.005 0.826 0.005 Download
ECFP6 fingerprints 0.899 0.006 0.957 0.003 0.928 0.004 0.926 0.005 0.970 0.000 0.856 0.005 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn