Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
| Uniprot primary ID | P18405 |
| PDB ID | |
| DrugBank ID | DB01126 DB01216 DB00421 DB00367 |
| BioGrid ID | 112593 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA36112 |
| KEGG ID | hsa:6715 |
| DIP ID | |
| STRING ID | 9606.ENSP00000274192 |
| IntAct ID | |
| DMDM | 134151 |
| BRENDA | 1.3.99.5 1.3.1.22 |
| Reactome | R-HSA-193048 |
| SignaLink | |
| BioCyc | MetaCyc:HS07261-MONOMER |
| Entrez Gene (Gene ID) | 6715 |
| BindingDB | P18405 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.890 | 0.000 | 0.950 | 0.000 | 0.920 | 0.000 | 0.920 | 0.000 | 0.978 | 0.004 | 0.850 | 0.000 | Download |
| Estate fingerprints | 0.882 | 0.006 | 0.850 | 0.005 | 0.866 | 0.005 | 0.867 | 0.005 | 0.940 | 0.000 | 0.729 | 0.007 | Download |
| MACCS fingerprints | 0.895 | 0.005 | 0.963 | 0.005 | 0.929 | 0.003 | 0.929 | 0.003 | 0.990 | 0.000 | 0.865 | 0.007 | Download |
| Daylight fingerprints | 0.828 | 0.008 | 0.934 | 0.007 | 0.881 | 0.003 | 0.874 | 0.005 | 0.941 | 0.003 | 0.765 | 0.007 | Download |
| ECFP2 fingerprints | 0.918 | 0.004 | 0.990 | 0.003 | 0.954 | 0.005 | 0.951 | 0.003 | 0.980 | 0.000 | 0.910 | 0.005 | Download |
| ECFP4 fingerprints | 0.918 | 0.004 | 1.000 | 0.005 | 0.960 | 0.000 | 0.958 | 0.004 | 0.990 | 0.000 | 0.921 | 0.007 | Download |
| ECFP6 fingerprints | 0.887 | 0.005 | 0.993 | 0.003 | 0.940 | 0.000 | 0.940 | 0.000 | 0.990 | 0.000 | 0.888 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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