TargetNet
  Target name

P18405: 3-oxo-5-alpha-steroid 4-dehydrogenase 1

  Protein function

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

  Database links
Uniprot primary ID P18405
PDB ID
DrugBank ID DB01126 DB01216 DB00421 DB00367
BioGrid ID 112593
GuidetoPHARMACOLOGY ID
PharmGKB ID PA36112
KEGG ID hsa:6715
DIP ID
STRING ID 9606.ENSP00000274192
IntAct ID
DMDM 134151
BRENDA 1.3.99.5 1.3.1.22
Reactome R-HSA-193048
SignaLink
BioCyc MetaCyc:HS07261-MONOMER
Entrez Gene (Gene ID) 6715
BindingDB P18405
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.890 0.000 0.950 0.000 0.920 0.000 0.920 0.000 0.978 0.004 0.850 0.000 Download
Estate fingerprints 0.882 0.006 0.850 0.005 0.866 0.005 0.867 0.005 0.940 0.000 0.729 0.007 Download
MACCS fingerprints 0.895 0.005 0.963 0.005 0.929 0.003 0.929 0.003 0.990 0.000 0.865 0.007 Download
Daylight fingerprints 0.828 0.008 0.934 0.007 0.881 0.003 0.874 0.005 0.941 0.003 0.765 0.007 Download
ECFP2 fingerprints 0.918 0.004 0.990 0.003 0.954 0.005 0.951 0.003 0.980 0.000 0.910 0.005 Download
ECFP4 fingerprints 0.918 0.004 1.000 0.005 0.960 0.000 0.958 0.004 0.990 0.000 0.921 0.007 Download
ECFP6 fingerprints 0.887 0.005 0.993 0.003 0.940 0.000 0.940 0.000 0.990 0.000 0.888 0.004 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn