Target name

P18405: 3-oxo-5-alpha-steroid 4-dehydrogenase 1


  Protein function

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

  Database links

Uniprot primary ID P18405
PDB ID
DrugBank ID DB01126 DB01216 DB00421 DB00367
BioGrid ID 112593
GuidetoPHARMACOLOGY ID
PharmGKB ID PA36112
KEGG ID hsa:6715
DIP ID
STRING ID 9606.ENSP00000274192
IntAct ID
DMDM 134151
BRENDA 1.3.99.5 1.3.1.22
Reactome R-HSA-193048
SignaLink
BioCyc MetaCyc:HS07261-MONOMER
Entrez Gene (Gene ID) 6715
BindingDB P18405

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.890 0.000 0.950 0.000 0.920 0.000 0.920 0.000 0.978 0.004 0.850 0.000 Download
Estate fingerprints 0.882 0.006 0.850 0.005 0.866 0.005 0.867 0.005 0.940 0.000 0.729 0.007 Download
MACCS fingerprints 0.895 0.005 0.963 0.005 0.929 0.003 0.929 0.003 0.990 0.000 0.865 0.007 Download
Daylight fingerprints 0.828 0.008 0.934 0.007 0.881 0.003 0.874 0.005 0.941 0.003 0.765 0.007 Download
ECFP2 fingerprints 0.918 0.004 0.990 0.003 0.954 0.005 0.951 0.003 0.980 0.000 0.910 0.005 Download
ECFP4 fingerprints 0.918 0.004 1.000 0.005 0.960 0.000 0.958 0.004 0.990 0.000 0.921 0.007 Download
ECFP6 fingerprints 0.887 0.005 0.993 0.003 0.940 0.000 0.940 0.000 0.990 0.000 0.888 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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