Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
| Uniprot primary ID | P18825 |
| PDB ID | |
| DrugBank ID | DB06148 DB00925 DB01142 DB01049 DB00734 DB00246 DB06694 |
| BioGrid ID | 106661 |
| GuidetoPHARMACOLOGY ID | 27 |
| PharmGKB ID | PA37 |
| KEGG ID | hsa:152 |
| DIP ID | |
| STRING ID | 9606.ENSP00000386069 |
| IntAct ID | |
| DMDM | 20141211 |
| BRENDA | |
| Reactome | R-HSA-400042 R-HSA-418594 R-HSA-418597 R-HSA-390696 R-HSA-392023 |
| SignaLink | P18825 |
| BioCyc | |
| Entrez Gene (Gene ID) | 152 |
| BindingDB | P18825 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.708 | 0.008 | 0.858 | 0.003 | 0.783 | 0.007 | 0.765 | 0.007 | 0.867 | 0.005 | 0.573 | 0.009 | Download |
| Estate fingerprints | 0.757 | 0.005 | 0.749 | 0.007 | 0.753 | 0.005 | 0.755 | 0.005 | 0.840 | 0.000 | 0.506 | 0.011 | Download |
| MACCS fingerprints | 0.814 | 0.011 | 0.726 | 0.006 | 0.770 | 0.007 | 0.779 | 0.007 | 0.866 | 0.005 | 0.541 | 0.011 | Download |
| Daylight fingerprints | 0.647 | 0.007 | 0.767 | 0.004 | 0.707 | 0.005 | 0.689 | 0.006 | 0.773 | 0.005 | 0.417 | 0.008 | Download |
| ECFP2 fingerprints | 0.871 | 0.007 | 0.835 | 0.009 | 0.853 | 0.005 | 0.855 | 0.005 | 0.940 | 0.000 | 0.705 | 0.011 | Download |
| ECFP4 fingerprints | 0.886 | 0.005 | 0.882 | 0.006 | 0.884 | 0.005 | 0.884 | 0.005 | 0.957 | 0.005 | 0.765 | 0.007 | Download |
| ECFP6 fingerprints | 0.855 | 0.005 | 0.945 | 0.003 | 0.900 | 0.000 | 0.894 | 0.005 | 0.960 | 0.000 | 0.802 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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