TargetNet
  Target name

P18825: Alpha-2C adrenergic receptor

  Protein function

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

  Database links
Uniprot primary ID P18825
PDB ID
DrugBank ID DB06148 DB00925 DB01142 DB01049 DB00734 DB00246 DB06694
BioGrid ID 106661
GuidetoPHARMACOLOGY ID 27
PharmGKB ID PA37
KEGG ID hsa:152
DIP ID
STRING ID 9606.ENSP00000386069
IntAct ID
DMDM 20141211
BRENDA
Reactome R-HSA-400042 R-HSA-418594 R-HSA-418597 R-HSA-390696 R-HSA-392023
SignaLink P18825
BioCyc
Entrez Gene (Gene ID) 152
BindingDB P18825
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.708 0.008 0.858 0.003 0.783 0.007 0.765 0.007 0.867 0.005 0.573 0.009 Download
Estate fingerprints 0.757 0.005 0.749 0.007 0.753 0.005 0.755 0.005 0.840 0.000 0.506 0.011 Download
MACCS fingerprints 0.814 0.011 0.726 0.006 0.770 0.007 0.779 0.007 0.866 0.005 0.541 0.011 Download
Daylight fingerprints 0.647 0.007 0.767 0.004 0.707 0.005 0.689 0.006 0.773 0.005 0.417 0.008 Download
ECFP2 fingerprints 0.871 0.007 0.835 0.009 0.853 0.005 0.855 0.005 0.940 0.000 0.705 0.011 Download
ECFP4 fingerprints 0.886 0.005 0.882 0.006 0.884 0.005 0.884 0.005 0.957 0.005 0.765 0.007 Download
ECFP6 fingerprints 0.855 0.005 0.945 0.003 0.900 0.000 0.894 0.005 0.960 0.000 0.802 0.004 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn