Target name

P18825: Alpha-2C adrenergic receptor


  Protein function

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

  Database links

Uniprot primary ID P18825
PDB ID
DrugBank ID DB06148 DB00925 DB01142 DB01049 DB00734 DB00246 DB06694
BioGrid ID 106661
GuidetoPHARMACOLOGY ID 27
PharmGKB ID PA37
KEGG ID hsa:152
DIP ID
STRING ID 9606.ENSP00000386069
IntAct ID
DMDM 20141211
BRENDA
Reactome R-HSA-400042 R-HSA-418594 R-HSA-418597 R-HSA-390696 R-HSA-392023
SignaLink P18825
BioCyc
Entrez Gene (Gene ID) 152
BindingDB P18825

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.708 0.008 0.858 0.003 0.783 0.007 0.765 0.007 0.867 0.005 0.573 0.009 Download
Estate fingerprints 0.757 0.005 0.749 0.007 0.753 0.005 0.755 0.005 0.840 0.000 0.506 0.011 Download
MACCS fingerprints 0.814 0.011 0.726 0.006 0.770 0.007 0.779 0.007 0.866 0.005 0.541 0.011 Download
Daylight fingerprints 0.647 0.007 0.767 0.004 0.707 0.005 0.689 0.006 0.773 0.005 0.417 0.008 Download
ECFP2 fingerprints 0.871 0.007 0.835 0.009 0.853 0.005 0.855 0.005 0.940 0.000 0.705 0.011 Download
ECFP4 fingerprints 0.886 0.005 0.882 0.006 0.884 0.005 0.884 0.005 0.957 0.005 0.765 0.007 Download
ECFP6 fingerprints 0.855 0.005 0.945 0.003 0.900 0.000 0.894 0.005 0.960 0.000 0.802 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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