Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.
| Uniprot primary ID | P19099 |
| PDB ID | 4FDH 4DVQ |
| DrugBank ID | DB01233 DB00741 DB00700 DB01011 DB00292 DB00421 |
| BioGrid ID | 107957 |
| GuidetoPHARMACOLOGY ID | 1360 |
| PharmGKB ID | PA134 |
| KEGG ID | hsa:1585 |
| DIP ID | |
| STRING ID | 9606.ENSP00000325822 |
| IntAct ID | |
| DMDM | 3041666 |
| BRENDA | 1.14.15.4 |
| Reactome | R-HSA-5579009 R-HSA-193993 R-HSA-194002 R-HSA-211976 |
| SignaLink | |
| BioCyc | MetaCyc:HS11355-MONOMER |
| Entrez Gene (Gene ID) | 1585 |
| BindingDB | P19099 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.972 | 0.006 | 0.938 | 0.004 | 0.955 | 0.005 | 0.955 | 0.005 | 0.990 | 0.000 | 0.911 | 0.006 | Download |
| Estate fingerprints | 0.875 | 0.005 | 0.865 | 0.005 | 0.870 | 0.000 | 0.870 | 0.000 | 0.950 | 0.000 | 0.738 | 0.006 | Download |
| MACCS fingerprints | 0.936 | 0.005 | 0.904 | 0.000 | 0.920 | 0.000 | 0.920 | 0.000 | 0.960 | 0.000 | 0.842 | 0.004 | Download |
| Daylight fingerprints | 0.823 | 0.005 | 0.815 | 0.004 | 0.819 | 0.003 | 0.819 | 0.003 | 0.860 | 0.000 | 0.636 | 0.005 | Download |
| ECFP2 fingerprints | 0.990 | 0.000 | 0.954 | 0.004 | 0.972 | 0.004 | 0.973 | 0.005 | 1.000 | 0.000 | 0.950 | 0.000 | Download |
| ECFP4 fingerprints | 0.997 | 0.005 | 0.969 | 0.000 | 0.983 | 0.005 | 0.983 | 0.005 | 1.000 | 0.000 | 0.970 | 0.000 | Download |
| ECFP6 fingerprints | 0.990 | 0.000 | 0.984 | 0.000 | 0.987 | 0.005 | 0.987 | 0.005 | 1.000 | 0.000 | 0.972 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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