Target name

P19099: Cytochrome P450 11B2, mitochondrial


  Protein function

Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.

  Database links

Uniprot primary ID P19099
PDB ID 4FDH 4DVQ
DrugBank ID DB01233 DB00741 DB00700 DB01011 DB00292 DB00421
BioGrid ID 107957
GuidetoPHARMACOLOGY ID 1360
PharmGKB ID PA134
KEGG ID hsa:1585
DIP ID
STRING ID 9606.ENSP00000325822
IntAct ID
DMDM 3041666
BRENDA 1.14.15.4
Reactome R-HSA-5579009 R-HSA-193993 R-HSA-194002 R-HSA-211976
SignaLink
BioCyc MetaCyc:HS11355-MONOMER
Entrez Gene (Gene ID) 1585
BindingDB P19099

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.972 0.006 0.938 0.004 0.955 0.005 0.955 0.005 0.990 0.000 0.911 0.006 Download
Estate fingerprints 0.875 0.005 0.865 0.005 0.870 0.000 0.870 0.000 0.950 0.000 0.738 0.006 Download
MACCS fingerprints 0.936 0.005 0.904 0.000 0.920 0.000 0.920 0.000 0.960 0.000 0.842 0.004 Download
Daylight fingerprints 0.823 0.005 0.815 0.004 0.819 0.003 0.819 0.003 0.860 0.000 0.636 0.005 Download
ECFP2 fingerprints 0.990 0.000 0.954 0.004 0.972 0.004 0.973 0.005 1.000 0.000 0.950 0.000 Download
ECFP4 fingerprints 0.997 0.005 0.969 0.000 0.983 0.005 0.983 0.005 1.000 0.000 0.970 0.000 Download
ECFP6 fingerprints 0.990 0.000 0.984 0.000 0.987 0.005 0.987 0.005 1.000 0.000 0.972 0.004 Download

  Download datasets

Positive dataset Negative dataset


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