Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
| Uniprot primary ID | P19320 |
| PDB ID | 1IJ9 1VSC 1VCA |
| DrugBank ID | DB00898 DB01136 |
| BioGrid ID | 113255 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA37286 |
| KEGG ID | hsa:7412 |
| DIP ID | |
| STRING ID | 9606.ENSP00000294728 |
| IntAct ID | P19320 |
| DMDM | 137560 |
| BRENDA | |
| Reactome | R-HSA-216083 R-HSA-877300 R-HSA-198933 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 7412 |
| BindingDB | P19320 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.867 | 0.008 | 0.989 | 0.005 | 0.928 | 0.004 | 0.919 | 0.003 | 0.990 | 0.000 | 0.857 | 0.007 | Download |
| Estate fingerprints | 0.896 | 0.010 | 0.798 | 0.006 | 0.847 | 0.007 | 0.852 | 0.006 | 0.919 | 0.003 | 0.695 | 0.015 | Download |
| MACCS fingerprints | 0.899 | 0.010 | 0.811 | 0.008 | 0.855 | 0.005 | 0.863 | 0.007 | 0.942 | 0.004 | 0.716 | 0.012 | Download |
| Daylight fingerprints | 0.800 | 0.007 | 0.996 | 0.000 | 0.898 | 0.004 | 0.885 | 0.005 | 0.980 | 0.000 | 0.810 | 0.007 | Download |
| ECFP2 fingerprints | 0.976 | 0.005 | 0.966 | 0.004 | 0.971 | 0.003 | 0.971 | 0.003 | 1.000 | 0.000 | 0.939 | 0.006 | Download |
| ECFP4 fingerprints | 0.970 | 0.000 | 0.990 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.960 | 0.000 | Download |
| ECFP6 fingerprints | 0.961 | 0.007 | 0.995 | 0.000 | 0.978 | 0.004 | 0.976 | 0.005 | 0.999 | 0.003 | 0.951 | 0.007 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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