Target name

P19320: Vascular cell adhesion protein 1


  Protein function

Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

  Database links

Uniprot primary ID P19320
PDB ID 1IJ9 1VSC 1VCA
DrugBank ID DB00898 DB01136
BioGrid ID 113255
GuidetoPHARMACOLOGY ID
PharmGKB ID PA37286
KEGG ID hsa:7412
DIP ID
STRING ID 9606.ENSP00000294728
IntAct ID P19320
DMDM 137560
BRENDA
Reactome R-HSA-216083 R-HSA-877300 R-HSA-198933
SignaLink
BioCyc
Entrez Gene (Gene ID) 7412
BindingDB P19320

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.867 0.008 0.989 0.005 0.928 0.004 0.919 0.003 0.990 0.000 0.857 0.007 Download
Estate fingerprints 0.896 0.010 0.798 0.006 0.847 0.007 0.852 0.006 0.919 0.003 0.695 0.015 Download
MACCS fingerprints 0.899 0.010 0.811 0.008 0.855 0.005 0.863 0.007 0.942 0.004 0.716 0.012 Download
Daylight fingerprints 0.800 0.007 0.996 0.000 0.898 0.004 0.885 0.005 0.980 0.000 0.810 0.007 Download
ECFP2 fingerprints 0.976 0.005 0.966 0.004 0.971 0.003 0.971 0.003 1.000 0.000 0.939 0.006 Download
ECFP4 fingerprints 0.970 0.000 0.990 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.960 0.000 Download
ECFP6 fingerprints 0.961 0.007 0.995 0.000 0.978 0.004 0.976 0.005 0.999 0.003 0.951 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn