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E-mail: biomed@csu.edu.cn
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G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
| Uniprot primary ID | P19327 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 1 |
| PharmGKB ID | |
| KEGG ID | rno:24473 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000013618 |
| IntAct ID | P19327 |
| DMDM | |
| BRENDA | |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 24473 |
| BindingDB | P19327 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.880 | 0.000 | 0.800 | 0.005 | 0.840 | 0.000 | 0.849 | 0.003 | 0.920 | 0.000 | 0.681 | 0.003 | Download |
| Estate fingerprints | 0.850 | 0.000 | 0.756 | 0.003 | 0.803 | 0.005 | 0.810 | 0.000 | 0.877 | 0.005 | 0.610 | 0.000 | Download |
| MACCS fingerprints | 0.891 | 0.003 | 0.731 | 0.000 | 0.811 | 0.003 | 0.830 | 0.000 | 0.900 | 0.000 | 0.638 | 0.004 | Download |
| Daylight fingerprints | 0.760 | 0.000 | 0.780 | 0.000 | 0.770 | 0.000 | 0.769 | 0.003 | 0.810 | 0.000 | 0.532 | 0.004 | Download |
| ECFP2 fingerprints | 0.940 | 0.000 | 0.900 | 0.000 | 0.920 | 0.000 | 0.920 | 0.000 | 0.970 | 0.000 | 0.847 | 0.005 | Download |
| ECFP4 fingerprints | 0.924 | 0.005 | 0.954 | 0.000 | 0.939 | 0.003 | 0.934 | 0.005 | 0.980 | 0.000 | 0.870 | 0.000 | Download |
| ECFP6 fingerprints | 0.879 | 0.003 | 0.961 | 0.000 | 0.920 | 0.000 | 0.920 | 0.000 | 0.980 | 0.000 | 0.843 | 0.005 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
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