Target name

P19634: Sodium/hydrogen exchanger 1


  Protein function

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.

  Database links

Uniprot primary ID P19634
PDB ID 2HTG 2E30 2BEC 2KBV 2MDF 2L0E 2YGG 1Y4E
DrugBank ID DB00594
BioGrid ID 112438
GuidetoPHARMACOLOGY ID
PharmGKB ID PA35928
KEGG ID hsa:6548
DIP ID
STRING ID 9606.ENSP00000263980
IntAct ID P19634
DMDM 127809
BRENDA
Reactome R-HSA-2160916 R-HSA-425986
SignaLink P19634
BioCyc
Entrez Gene (Gene ID) 6548
BindingDB P19634

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.901 0.009 0.973 0.004 0.937 0.005 0.935 0.005 0.990 0.000 0.876 0.007 Download
Estate fingerprints 0.882 0.004 0.918 0.005 0.900 0.000 0.899 0.003 0.943 0.005 0.795 0.005 Download
MACCS fingerprints 0.880 0.000 0.960 0.000 0.920 0.000 0.920 0.000 0.980 0.000 0.849 0.003 Download
Daylight fingerprints 0.879 0.009 0.977 0.007 0.928 0.006 0.922 0.004 0.980 0.000 0.859 0.007 Download
ECFP2 fingerprints 0.981 0.003 0.989 0.000 0.985 0.005 0.985 0.005 1.000 0.000 0.967 0.005 Download
ECFP4 fingerprints 0.999 0.003 0.993 0.000 0.996 0.005 0.996 0.005 1.000 0.000 0.989 0.003 Download
ECFP6 fingerprints 1.000 0.000 0.982 0.000 0.991 0.003 0.991 0.003 1.000 0.000 0.984 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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