Target name

P19643: Amine oxidase [flavin-containing] B


  Protein function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

  Database links

Uniprot primary ID P19643
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 2490
PharmGKB ID
KEGG ID rno:25750
DIP ID
STRING ID 10116.ENSRNOP00000043466
IntAct ID
DMDM
BRENDA 1.4.3.4
Reactome R-RNO-141333
SignaLink
BioCyc
Entrez Gene (Gene ID) 25750
BindingDB P19643

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.900 0.000 0.904 0.005 0.902 0.004 0.901 0.003 0.957 0.005 0.803 0.005 Download
Estate fingerprints 0.761 0.009 0.811 0.007 0.786 0.005 0.781 0.003 0.884 0.005 0.575 0.008 Download
MACCS fingerprints 0.888 0.004 0.828 0.004 0.858 0.004 0.860 0.000 0.930 0.000 0.716 0.007 Download
Daylight fingerprints 0.816 0.005 0.802 0.000 0.809 0.003 0.810 0.000 0.860 0.000 0.617 0.007 Download
ECFP2 fingerprints 0.922 0.004 0.906 0.007 0.914 0.005 0.914 0.005 0.980 0.000 0.828 0.006 Download
ECFP4 fingerprints 0.923 0.007 0.949 0.000 0.936 0.005 0.936 0.005 0.990 0.000 0.876 0.005 Download
ECFP6 fingerprints 0.898 0.004 0.976 0.005 0.937 0.005 0.934 0.005 0.990 0.000 0.874 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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