Target name

P19793: Retinoic acid receptor RXR-alpha


  Protein function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.

  Database links

Uniprot primary ID P19793
PDB ID 2NLL 3R29 1RDT 1G5Y 3NSQ 1K74 1XLS 2P1T 1MV9 3E00 3PCU 3FUG 1LBD 4M8E 4ZO1 1YNW 1FM6 3OZJ 3FC6 1FBY 1FM9 4M8H 3OAP 1XVP 3R5M 1G1U 3E94 2P1U 4J5X 2P1V 4N8R 4CN7 3KWY 2ZY0 4J5W 1RXR 4CN5 4N5G 3H0A 1BY4 4POH 1R0N 4K6I 4CN3 3NSP 4RFW 1XV9 4CN2 3FAL 4OC7 1MZN
DrugBank ID DB00307 DB00523 DB00459 DB00210 DB00749
BioGrid ID 112168
GuidetoPHARMACOLOGY ID 610
PharmGKB ID PA34890
KEGG ID
DIP ID DIP-641N
STRING ID 9606.ENSP00000419692
IntAct ID P19793
DMDM 133701
BRENDA
Reactome R-HSA-1989781 R-HSA-383280 R-HSA-193807 R-HSA-200425 R-HSA-192105 R-HSA-1368082 R-HSA-204174 R-HSA-159418 R-HSA-400206 R-HSA-381340 R-HSA-193368 R-HSA-2426168 R-HSA-2151201 R-HSA-211976 R-HSA-2032785 R-HSA-400253 R-HSA-1368108 R-HSA-5362517
SignaLink P19793
BioCyc
Entrez Gene (Gene ID) 6256
BindingDB P19793

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.892 0.004 0.960 0.000 0.926 0.005 0.921 0.003 0.980 0.000 0.851 0.006 Download
Estate fingerprints 0.930 0.000 0.908 0.006 0.919 0.003 0.920 0.000 0.970 0.000 0.833 0.005 Download
MACCS fingerprints 0.920 0.005 0.942 0.000 0.931 0.003 0.930 0.000 0.970 0.000 0.865 0.007 Download
Daylight fingerprints 0.842 0.004 0.986 0.003 0.914 0.005 0.909 0.003 0.970 0.000 0.838 0.006 Download
ECFP2 fingerprints 0.960 0.000 0.980 0.005 0.970 0.000 0.970 0.000 0.990 0.000 0.946 0.005 Download
ECFP4 fingerprints 0.960 0.000 0.998 0.005 0.979 0.003 0.979 0.003 0.994 0.005 0.958 0.004 Download
ECFP6 fingerprints 0.960 0.000 1.000 0.003 0.980 0.000 0.980 0.000 0.990 0.000 0.956 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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