Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
| Uniprot primary ID | P20292 |
| PDB ID | 2Q7R 2Q7M |
| DrugBank ID | |
| BioGrid ID | 106742 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA47 |
| KEGG ID | hsa:241 |
| DIP ID | |
| STRING ID | 9606.ENSP00000369858 |
| IntAct ID | P20292 |
| DMDM | 120267 |
| BRENDA | |
| Reactome | R-HSA-2142691 R-HSA-2142688 R-HSA-2142700 |
| SignaLink | |
| BioCyc | MetaCyc:ENSG00000132965-MONOMER |
| Entrez Gene (Gene ID) | 241 |
| BindingDB | P20292 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.969 | 0.003 | 0.989 | 0.000 | 0.979 | 0.003 | 0.979 | 0.003 | 0.989 | 0.003 | 0.958 | 0.006 | Download |
| Estate fingerprints | 0.908 | 0.004 | 0.924 | 0.000 | 0.916 | 0.005 | 0.913 | 0.005 | 0.970 | 0.000 | 0.829 | 0.003 | Download |
| MACCS fingerprints | 0.927 | 0.005 | 0.963 | 0.005 | 0.945 | 0.005 | 0.945 | 0.005 | 0.980 | 0.000 | 0.890 | 0.009 | Download |
| Daylight fingerprints | 0.946 | 0.008 | 0.992 | 0.003 | 0.969 | 0.003 | 0.967 | 0.005 | 0.980 | 0.000 | 0.940 | 0.008 | Download |
| ECFP2 fingerprints | 0.980 | 0.000 | 0.980 | 0.004 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.961 | 0.003 | Download |
| ECFP4 fingerprints | 0.980 | 0.000 | 0.982 | 0.003 | 0.981 | 0.003 | 0.981 | 0.003 | 1.000 | 0.000 | 0.970 | 0.000 | Download |
| ECFP6 fingerprints | 0.969 | 0.003 | 0.991 | 0.005 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.958 | 0.006 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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