Target name

P20292: Arachidonate 5-lipoxygenase-activating protein


  Protein function

Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.

  Database links

Uniprot primary ID P20292
PDB ID 2Q7R 2Q7M
DrugBank ID
BioGrid ID 106742
GuidetoPHARMACOLOGY ID
PharmGKB ID PA47
KEGG ID hsa:241
DIP ID
STRING ID 9606.ENSP00000369858
IntAct ID P20292
DMDM 120267
BRENDA
Reactome R-HSA-2142691 R-HSA-2142688 R-HSA-2142700
SignaLink
BioCyc MetaCyc:ENSG00000132965-MONOMER
Entrez Gene (Gene ID) 241
BindingDB P20292

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.969 0.003 0.989 0.000 0.979 0.003 0.979 0.003 0.989 0.003 0.958 0.006 Download
Estate fingerprints 0.908 0.004 0.924 0.000 0.916 0.005 0.913 0.005 0.970 0.000 0.829 0.003 Download
MACCS fingerprints 0.927 0.005 0.963 0.005 0.945 0.005 0.945 0.005 0.980 0.000 0.890 0.009 Download
Daylight fingerprints 0.946 0.008 0.992 0.003 0.969 0.003 0.967 0.005 0.980 0.000 0.940 0.008 Download
ECFP2 fingerprints 0.980 0.000 0.980 0.004 0.980 0.000 0.980 0.000 1.000 0.000 0.961 0.003 Download
ECFP4 fingerprints 0.980 0.000 0.982 0.003 0.981 0.003 0.981 0.003 1.000 0.000 0.970 0.000 Download
ECFP6 fingerprints 0.969 0.003 0.991 0.005 0.980 0.000 0.980 0.000 1.000 0.000 0.958 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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