The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
| Uniprot primary ID | P20309 |
| PDB ID | 2CSA |
| DrugBank ID | DB00777 DB01142 DB01062 DB00496 DB01625 DB00321 DB00202 |
| BioGrid ID | 107553 |
| GuidetoPHARMACOLOGY ID | 15 |
| PharmGKB ID | PA112 |
| KEGG ID | hsa:1131 |
| DIP ID | DIP-44291N |
| STRING ID | 9606.ENSP00000255380 |
| IntAct ID | P20309 |
| DMDM | 113125 |
| BRENDA | |
| Reactome | R-HSA-390648 R-HSA-399997 R-HSA-416476 |
| SignaLink | P20309 |
| BioCyc | |
| Entrez Gene (Gene ID) | 1131 |
| BindingDB | P20309 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.861 | 0.003 | 0.803 | 0.005 | 0.832 | 0.004 | 0.840 | 0.000 | 0.900 | 0.000 | 0.669 | 0.003 | Download |
| Estate fingerprints | 0.859 | 0.003 | 0.761 | 0.003 | 0.810 | 0.000 | 0.819 | 0.003 | 0.880 | 0.000 | 0.622 | 0.006 | Download |
| MACCS fingerprints | 0.900 | 0.000 | 0.740 | 0.000 | 0.820 | 0.000 | 0.839 | 0.003 | 0.910 | 0.000 | 0.654 | 0.005 | Download |
| Daylight fingerprints | 0.816 | 0.005 | 0.744 | 0.003 | 0.780 | 0.000 | 0.790 | 0.000 | 0.820 | 0.000 | 0.562 | 0.004 | Download |
| ECFP2 fingerprints | 0.899 | 0.003 | 0.921 | 0.000 | 0.910 | 0.000 | 0.909 | 0.003 | 0.970 | 0.000 | 0.822 | 0.006 | Download |
| ECFP4 fingerprints | 0.868 | 0.004 | 0.952 | 0.004 | 0.910 | 0.000 | 0.909 | 0.003 | 0.970 | 0.000 | 0.825 | 0.005 | Download |
| ECFP6 fingerprints | 0.828 | 0.004 | 0.972 | 0.000 | 0.900 | 0.000 | 0.890 | 0.000 | 0.970 | 0.000 | 0.807 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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