Target name

P20309: Muscarinic acetylcholine receptor M3


  Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

  Database links

Uniprot primary ID P20309
PDB ID 2CSA
DrugBank ID DB00777 DB01142 DB01062 DB00496 DB01625 DB00321 DB00202
BioGrid ID 107553
GuidetoPHARMACOLOGY ID 15
PharmGKB ID PA112
KEGG ID hsa:1131
DIP ID DIP-44291N
STRING ID 9606.ENSP00000255380
IntAct ID P20309
DMDM 113125
BRENDA
Reactome R-HSA-390648 R-HSA-399997 R-HSA-416476
SignaLink P20309
BioCyc
Entrez Gene (Gene ID) 1131
BindingDB P20309

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.861 0.003 0.803 0.005 0.832 0.004 0.840 0.000 0.900 0.000 0.669 0.003 Download
Estate fingerprints 0.859 0.003 0.761 0.003 0.810 0.000 0.819 0.003 0.880 0.000 0.622 0.006 Download
MACCS fingerprints 0.900 0.000 0.740 0.000 0.820 0.000 0.839 0.003 0.910 0.000 0.654 0.005 Download
Daylight fingerprints 0.816 0.005 0.744 0.003 0.780 0.000 0.790 0.000 0.820 0.000 0.562 0.004 Download
ECFP2 fingerprints 0.899 0.003 0.921 0.000 0.910 0.000 0.909 0.003 0.970 0.000 0.822 0.006 Download
ECFP4 fingerprints 0.868 0.004 0.952 0.004 0.910 0.000 0.909 0.003 0.970 0.000 0.825 0.005 Download
ECFP6 fingerprints 0.828 0.004 0.972 0.000 0.900 0.000 0.890 0.000 0.970 0.000 0.807 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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