TargetNet
  Target name

P20701: Integrin alpha-L

  Protein function

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.

  Database links
Uniprot primary ID P20701
PDB ID 3BQM 3BQN 3EOB 1DGQ 1LFA 3HI6 2ICA 1MQA 1MQ9 3TCX 4IXD 1CQP 1T0P 1IJ4 2O7N 3F78 2K8O 3F74 3EOA 1XUO 3M6F 1MQ8 1RD4 2M3E 1ZOP 3BN3 1XDG 1XDD 1ZON 1ZOO 1MJN 3E2M
DrugBank ID DB00098 DB00227 DB00095
BioGrid ID 109889
GuidetoPHARMACOLOGY ID 2451
PharmGKB ID PA29948
KEGG ID hsa:3683
DIP ID DIP-623N
STRING ID 9606.ENSP00000349252
IntAct ID P20701
DMDM 88911345
BRENDA
Reactome R-HSA-216083 R-HSA-198933 R-HSA-202733
SignaLink P20701
BioCyc
Entrez Gene (Gene ID) 3683
BindingDB P20701
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.899 0.003 0.969 0.003 0.934 0.005 0.931 0.003 0.980 0.000 0.871 0.006 Download
Estate fingerprints 0.799 0.003 0.805 0.008 0.802 0.004 0.802 0.004 0.900 0.000 0.603 0.008 Download
MACCS fingerprints 0.778 0.004 0.864 0.005 0.821 0.003 0.811 0.003 0.930 0.000 0.643 0.005 Download
Daylight fingerprints 0.759 0.006 0.993 0.004 0.876 0.005 0.859 0.006 0.940 0.000 0.772 0.006 Download
ECFP2 fingerprints 0.932 0.004 0.968 0.004 0.950 0.000 0.949 0.003 0.990 0.000 0.898 0.004 Download
ECFP4 fingerprints 0.959 0.003 0.991 0.000 0.975 0.005 0.972 0.004 1.000 0.000 0.949 0.003 Download
ECFP6 fingerprints 0.945 0.005 0.999 0.000 0.972 0.004 0.971 0.003 1.000 0.000 0.945 0.005 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn