Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
| Uniprot primary ID | P21451 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 220 |
| PharmGKB ID | |
| KEGG ID | rno:50672 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000014747 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | R-RNO-375276 R-RNO-416476 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 50672 |
| BindingDB | P21451 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.930 | 0.000 | 0.970 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 0.971 | 0.003 | 0.910 | 0.000 | Download |
| Estate fingerprints | 0.844 | 0.015 | 0.784 | 0.007 | 0.814 | 0.007 | 0.819 | 0.009 | 0.893 | 0.005 | 0.628 | 0.015 | Download |
| MACCS fingerprints | 0.925 | 0.013 | 0.897 | 0.012 | 0.911 | 0.010 | 0.911 | 0.010 | 0.972 | 0.004 | 0.825 | 0.021 | Download |
| Daylight fingerprints | 0.871 | 0.006 | 0.967 | 0.005 | 0.919 | 0.003 | 0.914 | 0.005 | 0.971 | 0.003 | 0.839 | 0.003 | Download |
| ECFP2 fingerprints | 0.934 | 0.008 | 0.934 | 0.003 | 0.934 | 0.005 | 0.935 | 0.005 | 0.979 | 0.003 | 0.871 | 0.009 | Download |
| ECFP4 fingerprints | 0.937 | 0.005 | 0.971 | 0.009 | 0.954 | 0.005 | 0.954 | 0.005 | 0.980 | 0.000 | 0.912 | 0.008 | Download |
| ECFP6 fingerprints | 0.926 | 0.008 | 0.988 | 0.004 | 0.957 | 0.005 | 0.957 | 0.005 | 0.982 | 0.004 | 0.911 | 0.007 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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