Target name

P21452: Substance-K receptor


  Protein function

This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.

  Database links

Uniprot primary ID P21452
PDB ID
DrugBank ID
BioGrid ID 112728
GuidetoPHARMACOLOGY ID 361
PharmGKB ID PA36303
KEGG ID hsa:6865
DIP ID
STRING ID 9606.ENSP00000362403
IntAct ID P21452
DMDM 229462950
BRENDA
Reactome R-HSA-380095 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 6865
BindingDB P21452

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.840 0.000 0.884 0.003 0.862 0.004 0.860 0.000 0.920 0.000 0.729 0.003 Download
Estate fingerprints 0.789 0.003 0.769 0.004 0.779 0.003 0.780 0.000 0.877 0.005 0.552 0.004 Download
MACCS fingerprints 0.797 0.005 0.783 0.003 0.790 0.000 0.790 0.000 0.880 0.000 0.580 0.000 Download
Daylight fingerprints 0.807 0.005 0.911 0.005 0.859 0.003 0.850 0.000 0.902 0.004 0.717 0.005 Download
ECFP2 fingerprints 0.839 0.006 0.937 0.005 0.888 0.004 0.884 0.005 0.958 0.004 0.779 0.006 Download
ECFP4 fingerprints 0.846 0.005 0.978 0.000 0.912 0.004 0.908 0.004 0.980 0.000 0.832 0.004 Download
ECFP6 fingerprints 0.832 0.004 0.988 0.005 0.910 0.000 0.901 0.003 0.980 0.000 0.827 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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