Target name

P21453: Sphingosine 1-phosphate receptor 1


  Protein function

G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.

  Database links

Uniprot primary ID P21453
PDB ID 3V2Y 3V2W
DrugBank ID
BioGrid ID 108225
GuidetoPHARMACOLOGY ID 275
PharmGKB ID PA162402344
KEGG ID hsa:1901
DIP ID DIP-60427N
STRING ID 9606.ENSP00000305416
IntAct ID P21453
DMDM 205371820
BRENDA
Reactome R-HSA-419408 R-HSA-418594
SignaLink P21453
BioCyc
Entrez Gene (Gene ID) 1901
BindingDB P21453

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.710 0.000 0.890 0.005 0.800 0.000 0.781 0.003 0.881 0.003 0.616 0.005 Download
Estate fingerprints 0.739 0.003 0.765 0.005 0.752 0.004 0.750 0.000 0.820 0.000 0.506 0.005 Download
MACCS fingerprints 0.736 0.005 0.816 0.005 0.776 0.005 0.767 0.005 0.848 0.004 0.554 0.005 Download
Daylight fingerprints 0.759 0.003 0.781 0.005 0.770 0.000 0.766 0.005 0.849 0.003 0.534 0.005 Download
ECFP2 fingerprints 0.804 0.005 0.902 0.003 0.853 0.005 0.848 0.004 0.930 0.000 0.710 0.005 Download
ECFP4 fingerprints 0.799 0.003 0.947 0.000 0.873 0.005 0.863 0.005 0.950 0.000 0.759 0.003 Download
ECFP6 fingerprints 0.775 0.005 0.965 0.000 0.870 0.000 0.860 0.000 0.940 0.000 0.752 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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