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E-mail: biomed@csu.edu.cn
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Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
| Uniprot primary ID | P21554 |
| PDB ID | 2KOE 1LVR 1LVQ 2B0Y |
| DrugBank ID | DB00470 DB06155 DB00486 |
| BioGrid ID | 107668 |
| GuidetoPHARMACOLOGY ID | 56 |
| PharmGKB ID | PA26681 |
| KEGG ID | hsa:1268 |
| DIP ID | |
| STRING ID | 9606.ENSP00000358511 |
| IntAct ID | P21554 |
| DMDM | 115562 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-373076 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 1268 |
| BindingDB | P21554 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.670 | 0.000 | 0.898 | 0.000 | 0.784 | 0.005 | 0.759 | 0.003 | 0.890 | 0.000 | 0.584 | 0.005 | Download |
| Estate fingerprints | 0.744 | 0.005 | 0.716 | 0.005 | 0.730 | 0.000 | 0.737 | 0.005 | 0.805 | 0.005 | 0.463 | 0.005 | Download |
| MACCS fingerprints | 0.740 | 0.000 | 0.740 | 0.000 | 0.740 | 0.000 | 0.740 | 0.000 | 0.830 | 0.000 | 0.481 | 0.003 | Download |
| Daylight fingerprints | 0.680 | 0.000 | 0.680 | 0.000 | 0.680 | 0.000 | 0.680 | 0.000 | 0.719 | 0.003 | 0.355 | 0.005 | Download |
| ECFP2 fingerprints | 0.869 | 0.003 | 0.893 | 0.000 | 0.881 | 0.003 | 0.880 | 0.000 | 0.950 | 0.000 | 0.770 | 0.000 | Download |
| ECFP4 fingerprints | 0.889 | 0.003 | 0.951 | 0.005 | 0.920 | 0.000 | 0.920 | 0.000 | 0.970 | 0.000 | 0.848 | 0.004 | Download |
| ECFP6 fingerprints | 0.851 | 0.003 | 0.969 | 0.000 | 0.910 | 0.000 | 0.902 | 0.004 | 0.970 | 0.000 | 0.822 | 0.004 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
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