Target name

P21554: Cannabinoid receptor 1


  Protein function

Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.

  Database links

Uniprot primary ID P21554
PDB ID 2KOE 1LVR 1LVQ 2B0Y
DrugBank ID DB00470 DB06155 DB00486
BioGrid ID 107668
GuidetoPHARMACOLOGY ID 56
PharmGKB ID PA26681
KEGG ID hsa:1268
DIP ID
STRING ID 9606.ENSP00000358511
IntAct ID P21554
DMDM 115562
BRENDA
Reactome R-HSA-418594 R-HSA-373076
SignaLink
BioCyc
Entrez Gene (Gene ID) 1268
BindingDB P21554

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.670 0.000 0.898 0.000 0.784 0.005 0.759 0.003 0.890 0.000 0.584 0.005 Download
Estate fingerprints 0.744 0.005 0.716 0.005 0.730 0.000 0.737 0.005 0.805 0.005 0.463 0.005 Download
MACCS fingerprints 0.740 0.000 0.740 0.000 0.740 0.000 0.740 0.000 0.830 0.000 0.481 0.003 Download
Daylight fingerprints 0.680 0.000 0.680 0.000 0.680 0.000 0.680 0.000 0.719 0.003 0.355 0.005 Download
ECFP2 fingerprints 0.869 0.003 0.893 0.000 0.881 0.003 0.880 0.000 0.950 0.000 0.770 0.000 Download
ECFP4 fingerprints 0.889 0.003 0.951 0.005 0.920 0.000 0.920 0.000 0.970 0.000 0.848 0.004 Download
ECFP6 fingerprints 0.851 0.003 0.969 0.000 0.910 0.000 0.902 0.004 0.970 0.000 0.822 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn