Target name

P21728: D(1A) dopamine receptor


  Protein function

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

  Database links

Uniprot primary ID P21728
PDB ID 1OZ5
DrugBank ID DB00777 DB06148 DB01063 DB01624 DB01608 DB01623 DB00246
BioGrid ID 108146
GuidetoPHARMACOLOGY ID 214
PharmGKB ID PA147
KEGG ID hsa:1812
DIP ID
STRING ID 9606.ENSP00000327652
IntAct ID
DMDM 118228
BRENDA
Reactome R-HSA-418555 R-HSA-390651
SignaLink
BioCyc
Entrez Gene (Gene ID) 1812
BindingDB P21728

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.590 0.000 0.930 0.005 0.760 0.000 0.710 0.000 0.820 0.000 0.557 0.005 Download
Estate fingerprints 0.691 0.003 0.749 0.005 0.720 0.000 0.710 0.000 0.790 0.000 0.440 0.005 Download
MACCS fingerprints 0.720 0.000 0.722 0.003 0.721 0.003 0.720 0.000 0.810 0.000 0.449 0.003 Download
Daylight fingerprints 0.545 0.005 0.899 0.000 0.722 0.004 0.662 0.004 0.780 0.000 0.479 0.006 Download
ECFP2 fingerprints 0.769 0.006 0.851 0.003 0.810 0.000 0.800 0.000 0.900 0.000 0.619 0.006 Download
ECFP4 fingerprints 0.713 0.005 0.907 0.000 0.810 0.000 0.791 0.003 0.910 0.000 0.636 0.005 Download
ECFP6 fingerprints 0.668 0.004 0.932 0.005 0.800 0.000 0.770 0.000 0.900 0.000 0.620 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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