TargetNet
  Target name

P22001: Potassium voltage-gated channel subfamily A member 3

  Protein function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

  Database links
Uniprot primary ID P22001
PDB ID 4BGC
DrugBank ID DB06637
BioGrid ID 109941
GuidetoPHARMACOLOGY ID 540
PharmGKB ID PA30021
KEGG ID hsa:3738
DIP ID DIP-44822N
STRING ID 9606.ENSP00000358784
IntAct ID
DMDM 215274135
BRENDA
Reactome R-HSA-1296072
SignaLink
BioCyc
Entrez Gene (Gene ID) 3738
BindingDB P22001
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.826 0.005 0.958 0.003 0.892 0.004 0.886 0.005 0.960 0.000 0.794 0.008 Download
Estate fingerprints 0.890 0.007 0.752 0.005 0.821 0.006 0.832 0.006 0.899 0.003 0.648 0.010 Download
MACCS fingerprints 0.775 0.005 0.857 0.012 0.816 0.005 0.807 0.005 0.892 0.004 0.631 0.012 Download
Daylight fingerprints 0.678 0.006 0.998 0.005 0.838 0.004 0.805 0.007 0.931 0.003 0.712 0.004 Download
ECFP2 fingerprints 0.908 0.006 0.976 0.005 0.942 0.004 0.941 0.003 0.990 0.000 0.890 0.007 Download
ECFP4 fingerprints 0.918 0.004 0.996 0.000 0.957 0.005 0.954 0.005 0.990 0.000 0.913 0.007 Download
ECFP6 fingerprints 0.901 0.006 0.999 0.000 0.950 0.005 0.949 0.003 1.000 0.000 0.902 0.006 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn