TargetNet
  Target name

P22086: Alpha-2C adrenergic receptor

  Protein function

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

  Database links
Uniprot primary ID P22086
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 27
PharmGKB ID
KEGG ID rno:24175
DIP ID
STRING ID 10116.ENSRNOP00000012322
IntAct ID
DMDM
BRENDA
Reactome R-RNO-392023 R-RNO-418594 R-RNO-418597 R-RNO-390696 R-RNO-400042
SignaLink
BioCyc
Entrez Gene (Gene ID) 24175
BindingDB P22086
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.731 0.018 0.761 0.006 0.746 0.012 0.742 0.013 0.829 0.006 0.494 0.023 Download
Estate fingerprints 0.690 0.009 0.748 0.018 0.719 0.007 0.711 0.007 0.798 0.004 0.438 0.019 Download
MACCS fingerprints 0.748 0.010 0.740 0.016 0.744 0.011 0.744 0.010 0.809 0.003 0.490 0.019 Download
Daylight fingerprints 0.672 0.006 0.802 0.003 0.737 0.007 0.717 0.007 0.780 0.000 0.476 0.010 Download
ECFP2 fingerprints 0.845 0.005 0.743 0.010 0.794 0.005 0.804 0.005 0.887 0.005 0.591 0.009 Download
ECFP4 fingerprints 0.888 0.010 0.760 0.009 0.824 0.008 0.835 0.007 0.922 0.009 0.651 0.014 Download
ECFP6 fingerprints 0.860 0.011 0.758 0.025 0.809 0.014 0.819 0.011 0.909 0.007 0.624 0.026 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn