Target name

P22086: Alpha-2C adrenergic receptor


  Protein function

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

  Database links

Uniprot primary ID P22086
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 27
PharmGKB ID
KEGG ID rno:24175
DIP ID
STRING ID 10116.ENSRNOP00000012322
IntAct ID
DMDM
BRENDA
Reactome R-RNO-392023 R-RNO-418594 R-RNO-418597 R-RNO-390696 R-RNO-400042
SignaLink
BioCyc
Entrez Gene (Gene ID) 24175
BindingDB P22086

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.731 0.018 0.761 0.006 0.746 0.012 0.742 0.013 0.829 0.006 0.494 0.023 Download
Estate fingerprints 0.690 0.009 0.748 0.018 0.719 0.007 0.711 0.007 0.798 0.004 0.438 0.019 Download
MACCS fingerprints 0.748 0.010 0.740 0.016 0.744 0.011 0.744 0.010 0.809 0.003 0.490 0.019 Download
Daylight fingerprints 0.672 0.006 0.802 0.003 0.737 0.007 0.717 0.007 0.780 0.000 0.476 0.010 Download
ECFP2 fingerprints 0.845 0.005 0.743 0.010 0.794 0.005 0.804 0.005 0.887 0.005 0.591 0.009 Download
ECFP4 fingerprints 0.888 0.010 0.760 0.009 0.824 0.008 0.835 0.007 0.922 0.009 0.651 0.014 Download
ECFP6 fingerprints 0.860 0.011 0.758 0.025 0.809 0.014 0.819 0.011 0.909 0.007 0.624 0.026 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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