Target name

P22303: Acetylcholinesterase


  Protein function

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.

  Database links

Uniprot primary ID P22303
PDB ID 1B41 2X8B 1F8U 4EY4 1PUV 1PUW 4M0E 4BDT 4M0F 3LII 4EY5 1VZJ 2CLJ 4EY6 4EY8 4PQE 4EY7
DrugBank ID DB00843 DB00944 DB00981 DB01364 DB00733 DB08996 DB00545
BioGrid ID 106561
GuidetoPHARMACOLOGY ID 2465
PharmGKB ID PA20
KEGG ID hsa:43
DIP ID DIP-1119N
STRING ID 9606.ENSP00000303211
IntAct ID P22303
DMDM 113037
BRENDA 3.1.1.7
Reactome R-HSA-112311 R-HSA-1483191 R-HSA-422085
SignaLink
BioCyc
Entrez Gene (Gene ID) 43
BindingDB P22303

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.840 0.000 0.840 0.000 0.840 0.000 0.840 0.000 0.910 0.000 0.678 0.004 Download
Estate fingerprints 0.779 0.003 0.729 0.005 0.754 0.005 0.758 0.004 0.820 0.000 0.508 0.006 Download
MACCS fingerprints 0.850 0.000 0.710 0.000 0.780 0.000 0.790 0.000 0.860 0.000 0.566 0.005 Download
Daylight fingerprints 0.750 0.000 0.790 0.000 0.770 0.000 0.760 0.000 0.806 0.005 0.539 0.003 Download
ECFP2 fingerprints 0.930 0.000 0.902 0.000 0.916 0.005 0.918 0.004 0.970 0.000 0.832 0.004 Download
ECFP4 fingerprints 0.901 0.003 0.959 0.000 0.930 0.000 0.924 0.005 0.980 0.000 0.858 0.004 Download
ECFP6 fingerprints 0.841 0.003 0.979 0.003 0.910 0.000 0.900 0.000 0.980 0.000 0.823 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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