Target name

P22460: Potassium voltage-gated channel subfamily A member 5


  Protein function

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed:11524461).

  Database links

Uniprot primary ID P22460
PDB ID
DrugBank ID DB06637
BioGrid ID 109943
GuidetoPHARMACOLOGY ID 542
PharmGKB ID PA208
KEGG ID hsa:3741
DIP ID DIP-42010N
STRING ID 9606.ENSP00000252321
IntAct ID P22460
DMDM 146345443
BRENDA
Reactome R-HSA-1296072
SignaLink
BioCyc
Entrez Gene (Gene ID) 3741
BindingDB P22460

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.606 0.005 0.994 0.003 0.800 0.000 0.752 0.004 0.930 0.000 0.652 0.004 Download
Estate fingerprints 0.773 0.005 0.693 0.003 0.733 0.005 0.744 0.005 0.830 0.000 0.470 0.008 Download
MACCS fingerprints 0.672 0.004 0.812 0.003 0.742 0.004 0.724 0.005 0.819 0.003 0.491 0.006 Download
Daylight fingerprints 0.639 0.006 0.761 0.000 0.700 0.000 0.682 0.004 0.750 0.000 0.405 0.005 Download
ECFP2 fingerprints 0.921 0.003 0.949 0.003 0.935 0.005 0.935 0.005 0.980 0.000 0.870 0.005 Download
ECFP4 fingerprints 0.915 0.005 0.985 0.004 0.950 0.000 0.949 0.003 0.990 0.000 0.901 0.006 Download
ECFP6 fingerprints 0.893 0.005 0.993 0.000 0.943 0.005 0.940 0.000 0.990 0.000 0.892 0.006 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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