TargetNet
  Target name

P22748: Carbonic anhydrase 4

  Protein function

Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.

  Database links
Uniprot primary ID P22748
PDB ID 1ZNC 3F7B 3F7U 3FW3
DrugBank ID DB01144 DB01194 DB01021 DB00880 DB00869 DB00606 DB00703
BioGrid ID 107217
GuidetoPHARMACOLOGY ID 2599
PharmGKB ID PA25991
KEGG ID hsa:762
DIP ID
STRING ID 9606.ENSP00000300900
IntAct ID P22748
DMDM 115465
BRENDA 4.2.1.1
Reactome R-HSA-1247673 R-HSA-1237044 R-HSA-1475029
SignaLink
BioCyc
Entrez Gene (Gene ID) 762
BindingDB P22748
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.926 0.005 0.880 0.007 0.903 0.005 0.906 0.005 0.969 0.003 0.804 0.008 Download
Estate fingerprints 0.892 0.006 0.882 0.006 0.887 0.005 0.887 0.005 0.950 0.000 0.771 0.007 Download
MACCS fingerprints 0.826 0.005 0.828 0.005 0.827 0.005 0.827 0.005 0.927 0.005 0.655 0.007 Download
Daylight fingerprints 0.657 0.005 0.841 0.000 0.749 0.003 0.726 0.005 0.810 0.000 0.507 0.005 Download
ECFP2 fingerprints 0.968 0.006 0.926 0.003 0.947 0.005 0.948 0.004 0.980 0.000 0.892 0.004 Download
ECFP4 fingerprints 0.971 0.007 0.925 0.007 0.948 0.008 0.949 0.007 0.990 0.000 0.900 0.016 Download
ECFP6 fingerprints 0.955 0.005 0.945 0.003 0.950 0.000 0.950 0.000 0.990 0.000 0.900 0.000 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn