Target name

P22894: Neutrophil collagenase


  Protein function

Can degrade fibrillar type I, II, and III collagens.

  Database links

Uniprot primary ID P22894
PDB ID 2OY2 2OY4 3DNG 1JAP 1JAQ 1JAN 1JAO 1A86 1I76 4QKZ 1A85 1I73 1ZS0 1ZVX 1JH1 1JJ9 1MMB 1ZP5 3DPE 3DPF 1KBC 3TT4 1BZS 1MNC
DrugBank ID DB00786
BioGrid ID 110460
GuidetoPHARMACOLOGY ID 1632
PharmGKB ID PA30888
KEGG ID hsa:4317
DIP ID
STRING ID 9606.ENSP00000236826
IntAct ID
DMDM 116862
BRENDA 3.4.24.34
Reactome R-HSA-1592389 R-HSA-1474228 R-HSA-1442490
SignaLink
BioCyc
Entrez Gene (Gene ID) 4317
BindingDB P22894

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.932 0.004 0.908 0.000 0.920 0.000 0.920 0.000 0.970 0.000 0.843 0.005 Download
Estate fingerprints 0.910 0.000 0.848 0.004 0.879 0.003 0.880 0.000 0.950 0.000 0.759 0.003 Download
MACCS fingerprints 0.909 0.003 0.871 0.003 0.890 0.000 0.890 0.000 0.960 0.000 0.780 0.000 Download
Daylight fingerprints 0.762 0.004 0.940 0.000 0.851 0.003 0.840 0.000 0.950 0.000 0.714 0.005 Download
ECFP2 fingerprints 0.964 0.005 0.922 0.000 0.943 0.005 0.947 0.005 0.990 0.000 0.890 0.000 Download
ECFP4 fingerprints 0.969 0.003 0.949 0.005 0.959 0.003 0.960 0.000 0.990 0.000 0.918 0.004 Download
ECFP6 fingerprints 0.950 0.000 0.970 0.005 0.960 0.000 0.960 0.000 0.990 0.000 0.916 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn