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Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.
| Uniprot primary ID | P23141 |
| PDB ID | 2H7C 1YA8 2DQZ 2DQY 4AB1 3K9B 1YA4 2HRR 2HRQ 1YAH 1YAJ 1MX1 1MX5 2DR0 1MX9 |
| DrugBank ID | DB00328 DB00762 DB02659 DB00758 DB01101 DB00688 DB06201 |
| BioGrid ID | 107494 |
| GuidetoPHARMACOLOGY ID | 2592 |
| PharmGKB ID | PA107 |
| KEGG ID | hsa:1066 |
| DIP ID | |
| STRING ID | 9606.ENSP00000353720 |
| IntAct ID | P23141 |
| DMDM | 119576 |
| BRENDA | 3.1.1.1 |
| Reactome | |
| SignaLink | |
| BioCyc | MetaCyc:HS11616-MONOMER |
| Entrez Gene (Gene ID) | 1066 |
| BindingDB | P23141 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.978 | 0.004 | 0.926 | 0.006 | 0.952 | 0.004 | 0.952 | 0.004 | 0.990 | 0.000 | 0.903 | 0.007 | Download |
| Estate fingerprints | 0.916 | 0.005 | 0.904 | 0.005 | 0.910 | 0.000 | 0.910 | 0.000 | 0.970 | 0.000 | 0.814 | 0.005 | Download |
| MACCS fingerprints | 0.905 | 0.005 | 0.919 | 0.005 | 0.912 | 0.004 | 0.910 | 0.005 | 0.961 | 0.003 | 0.824 | 0.008 | Download |
| Daylight fingerprints | 0.765 | 0.008 | 0.855 | 0.000 | 0.810 | 0.005 | 0.801 | 0.006 | 0.885 | 0.005 | 0.621 | 0.006 | Download |
| ECFP2 fingerprints | 0.970 | 0.000 | 0.920 | 0.007 | 0.945 | 0.005 | 0.945 | 0.005 | 0.990 | 0.000 | 0.891 | 0.007 | Download |
| ECFP4 fingerprints | 0.991 | 0.006 | 0.909 | 0.005 | 0.950 | 0.000 | 0.950 | 0.000 | 0.995 | 0.005 | 0.902 | 0.004 | Download |
| ECFP6 fingerprints | 0.980 | 0.007 | 0.936 | 0.005 | 0.958 | 0.004 | 0.958 | 0.004 | 0.995 | 0.005 | 0.918 | 0.006 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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