Details-Calcnet-TargetNet

Target name

P23219: Prostaglandin G/H synthase 1

Protein function

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.

Database links

Uniprot primary ID	P23219
PDB ID
DrugBank ID	DB01419 DB00619 DB00159 DB00773 DB01029 DB01435 DB01221
BioGrid ID	111714
GuidetoPHARMACOLOGY ID	1375
PharmGKB ID	PA24346
KEGG ID	hsa:5742
DIP ID
STRING ID	9606.ENSP00000354612
IntAct ID	P23219
DMDM	317373262
BRENDA	1.14.99.1
Reactome	R-HSA-140180 R-HSA-2162123
SignaLink
BioCyc	MetaCyc:HS01815-MONOMER
Entrez Gene (Gene ID)	5742
BindingDB	P23219

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.841	0.014	0.853	0.008	0.847	0.007	0.846	0.008	0.924	0.005	0.697	0.012	Download
Estate fingerprints	0.725	0.007	0.837	0.007	0.781	0.006	0.769	0.006	0.892	0.004	0.566	0.012	Download
MACCS fingerprints	0.797	0.005	0.813	0.005	0.805	0.005	0.805	0.005	0.893	0.005	0.616	0.010	Download
Daylight fingerprints	0.651	0.006	0.813	0.004	0.732	0.004	0.710	0.007	0.820	0.000	0.475	0.008	Download
ECFP2 fingerprints	0.875	0.005	0.863	0.011	0.869	0.007	0.869	0.007	0.952	0.004	0.737	0.012	Download
ECFP4 fingerprints	0.907	0.005	0.873	0.012	0.890	0.007	0.891	0.006	0.970	0.000	0.779	0.012	Download
ECFP6 fingerprints	0.890	0.012	0.926	0.007	0.908	0.006	0.906	0.007	0.970	0.000	0.816	0.013	Download

Download datasets

Positive dataset

Negative dataset