Target name

P23219: Prostaglandin G/H synthase 1


  Protein function

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.

  Database links

Uniprot primary ID P23219
PDB ID
DrugBank ID DB01419 DB00619 DB00159 DB00773 DB01029 DB01435 DB01221
BioGrid ID 111714
GuidetoPHARMACOLOGY ID 1375
PharmGKB ID PA24346
KEGG ID hsa:5742
DIP ID
STRING ID 9606.ENSP00000354612
IntAct ID P23219
DMDM 317373262
BRENDA 1.14.99.1
Reactome R-HSA-140180 R-HSA-2162123
SignaLink
BioCyc MetaCyc:HS01815-MONOMER
Entrez Gene (Gene ID) 5742
BindingDB P23219

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.841 0.014 0.853 0.008 0.847 0.007 0.846 0.008 0.924 0.005 0.697 0.012 Download
Estate fingerprints 0.725 0.007 0.837 0.007 0.781 0.006 0.769 0.006 0.892 0.004 0.566 0.012 Download
MACCS fingerprints 0.797 0.005 0.813 0.005 0.805 0.005 0.805 0.005 0.893 0.005 0.616 0.010 Download
Daylight fingerprints 0.651 0.006 0.813 0.004 0.732 0.004 0.710 0.007 0.820 0.000 0.475 0.008 Download
ECFP2 fingerprints 0.875 0.005 0.863 0.011 0.869 0.007 0.869 0.007 0.952 0.004 0.737 0.012 Download
ECFP4 fingerprints 0.907 0.005 0.873 0.012 0.890 0.007 0.891 0.006 0.970 0.000 0.779 0.012 Download
ECFP6 fingerprints 0.890 0.012 0.926 0.007 0.908 0.006 0.906 0.007 0.970 0.000 0.816 0.013 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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