G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.
| Uniprot primary ID | P23385 |
| PDB ID | 1EWK 1ISR 1EWV 1ISS 1EWT |
| DrugBank ID | |
| BioGrid ID | 246579 |
| GuidetoPHARMACOLOGY ID | 289 |
| PharmGKB ID | |
| KEGG ID | rno:24414 |
| DIP ID | DIP-44897N |
| STRING ID | 10116.ENSRNOP00000019319 |
| IntAct ID | P23385 |
| DMDM | |
| BRENDA | |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 24414 |
| BindingDB | P23385 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.596 | 0.005 | 0.974 | 0.005 | 0.785 | 0.005 | 0.734 | 0.005 | 0.950 | 0.000 | 0.617 | 0.007 | Download |
| Estate fingerprints | 0.713 | 0.005 | 0.797 | 0.005 | 0.755 | 0.005 | 0.745 | 0.005 | 0.860 | 0.000 | 0.511 | 0.007 | Download |
| MACCS fingerprints | 0.827 | 0.005 | 0.851 | 0.006 | 0.839 | 0.003 | 0.837 | 0.005 | 0.930 | 0.000 | 0.677 | 0.005 | Download |
| Daylight fingerprints | 0.521 | 0.007 | 0.993 | 0.000 | 0.757 | 0.005 | 0.682 | 0.006 | 0.902 | 0.004 | 0.581 | 0.006 | Download |
| ECFP2 fingerprints | 0.881 | 0.007 | 0.955 | 0.000 | 0.918 | 0.004 | 0.917 | 0.005 | 0.980 | 0.000 | 0.838 | 0.006 | Download |
| ECFP4 fingerprints | 0.922 | 0.006 | 0.976 | 0.004 | 0.949 | 0.003 | 0.946 | 0.005 | 0.990 | 0.000 | 0.897 | 0.008 | Download |
| ECFP6 fingerprints | 0.888 | 0.004 | 0.978 | 0.000 | 0.933 | 0.005 | 0.931 | 0.003 | 0.990 | 0.000 | 0.872 | 0.006 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: jiedong@csu.edu.cn
 |
 |
 |
 |
 |
 |