Target name

P23385: Metabotropic glutamate receptor 1


  Protein function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.

  Database links

Uniprot primary ID P23385
PDB ID 1EWK 1ISR 1EWV 1ISS 1EWT
DrugBank ID
BioGrid ID 246579
GuidetoPHARMACOLOGY ID 289
PharmGKB ID
KEGG ID rno:24414
DIP ID DIP-44897N
STRING ID 10116.ENSRNOP00000019319
IntAct ID P23385
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 24414
BindingDB P23385

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.596 0.005 0.974 0.005 0.785 0.005 0.734 0.005 0.950 0.000 0.617 0.007 Download
Estate fingerprints 0.713 0.005 0.797 0.005 0.755 0.005 0.745 0.005 0.860 0.000 0.511 0.007 Download
MACCS fingerprints 0.827 0.005 0.851 0.006 0.839 0.003 0.837 0.005 0.930 0.000 0.677 0.005 Download
Daylight fingerprints 0.521 0.007 0.993 0.000 0.757 0.005 0.682 0.006 0.902 0.004 0.581 0.006 Download
ECFP2 fingerprints 0.881 0.007 0.955 0.000 0.918 0.004 0.917 0.005 0.980 0.000 0.838 0.006 Download
ECFP4 fingerprints 0.922 0.006 0.976 0.004 0.949 0.003 0.946 0.005 0.990 0.000 0.897 0.008 Download
ECFP6 fingerprints 0.888 0.004 0.978 0.000 0.933 0.005 0.931 0.003 0.990 0.000 0.872 0.006 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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