Target name

P23458: Tyrosine-protein kinase JAK1


  Protein function

Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.

  Database links

Uniprot primary ID P23458
PDB ID 4EHZ 3EYG 4K77 4K6Z 4E5W 3EYH 4FK6 4GS0 4L00 4E4L 4EI4 4E4N 4I5C 4IVD 4IVC 4IVB 4L01
DrugBank ID DB08877 DB08895
BioGrid ID 109919
GuidetoPHARMACOLOGY ID 2047
PharmGKB ID PA29988
KEGG ID hsa:3716
DIP ID DIP-133N
STRING ID 9606.ENSP00000343204
IntAct ID P23458
DMDM 215274013
BRENDA 2.7.10.2
Reactome R-HSA-1059683 R-HSA-1266695 R-HSA-114604 R-HSA-912526 R-HSA-451927 R-HSA-392451 R-HSA-112411 R-HSA-877312 R-HSA-912694 R-HSA-877300 R-HSA-1169408 R-HSA-909733 R-HSA-110056 R-HSA-5673001
SignaLink P23458
BioCyc
Entrez Gene (Gene ID) 3716
BindingDB P23458

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.899 0.003 0.907 0.005 0.903 0.005 0.901 0.003 0.956 0.005 0.806 0.005 Download
Estate fingerprints 0.786 0.013 0.788 0.006 0.787 0.005 0.788 0.006 0.882 0.004 0.578 0.012 Download
MACCS fingerprints 0.825 0.008 0.775 0.007 0.800 0.007 0.808 0.006 0.900 0.000 0.605 0.011 Download
Daylight fingerprints 0.802 0.006 0.896 0.011 0.849 0.007 0.841 0.007 0.920 0.000 0.701 0.015 Download
ECFP2 fingerprints 0.928 0.008 0.920 0.006 0.924 0.005 0.924 0.005 0.980 0.000 0.849 0.009 Download
ECFP4 fingerprints 0.923 0.005 0.959 0.006 0.941 0.003 0.941 0.003 0.980 0.000 0.887 0.007 Download
ECFP6 fingerprints 0.900 0.000 0.992 0.000 0.946 0.005 0.940 0.000 0.970 0.000 0.896 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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